Pigeon circovirus (PiCV), also known as Columbid Circovirus or CoCV, is the most common virus in pigeons and has been linked to Young Pigeon Disease Syndrome (YPDS). PiCV was discovered in Canada in 1986. It is now thought to have a global distribution and has been detected in Europe, Asia, North America, South Africa, and Australia, infecting both racing and meat pigeons. This virus is thought to harm the immune system and invite secondary infections with other viruses, resulting in a variety of health issues. Circovirus-infected pigeons are more susceptible to other common diseases. The symptoms observed are frequently the result of another secondary infection rather than the circovirus itself. As a result, pigeon circovirus is referred to as pigeon AIDS in some parts of the world. Creative Biolabs is now dedicated to facilitating veterinary research by expanding our viroantibody product line on a regular basis. We supply anti-PiCV antibodies to help PiCV research.
Fig.1 Countries with reported detection of PiCV. (Silva, et al., 2022)
Structure of PiCV
PiCV is a member of the Circovirus genus and the Circoviridae family. PiCV, like most other Circoviridae viruses, is a small non-enveloped icosahedral virus with a diameter of 15-20 nm. The genome is a circular, single-stranded, ambisense DNA of about 2 kb in size that replicates using rolling circle replication. Circoviruses have five open reading frames encoded by the ori on the same strand (ORFs). ORF V1 encodes replicase and is found on the virion sense strand (Rep protein). ORF C1 encodes the viral capsid protein and is found on the complementary sense strand (Cap protein). The other ORFs, ORF-C2, ORF-C3, and ORF-C4, encode three viral proteins that are thought to contribute to PiCV pathogenesis but are unknown.
Fig.2 Schematic diagram of the organization of PiCV genomes. (Stenzel & Koncicki, 2017)
Diagnosis
PiCV multiplication in cell cultures and embryonated egg inoculation, like all other tests, fail. Standard PCR, Real-time PCR, NGS techniques, and the loop-mediated isothermal amplification method enabled more rapid and accurate detection of PiCV infections. The PiCV genome's more conservative rep region is better suited for designing PCR primers.
Anti-PiCV antibodies
Creative Biolabs is dedicated to providing high-quality, all-inclusive antibodies for veterinary and animal research. We offer anti-PiCV antibodies to meet your requirements. We also offer antibodies against other circoviruses, such as canine circovirus, porcine circovirus, etc.. We also offer customized antibody development services for anti-circovirus antibodies, including antibody discovery, engineering, and customized services. Please send us your specific anti-PiCV antibody inquiry, and we will respond as soon as possible.
To begin your research, browse our entire catalog of PiCV antibodies.
References
- Silva, B.B.I.; et al. Pigeon circovirus over three decades of research: bibliometrics, scoping review, and perspectives. Viruses. 2022, 14(7): 1498.
- Stenzel, T.; Koncicki, A. The epidemiology, molecular characterization and clinical pathology of circovirus infections in pigeons–current knowledge. Veterinary Quarterly. 2017, 37(1): 166-174.
