Anti-HRSV Drug Discovery Products

Human Orthopneumovirus (human respiratory syncytial virus, HRSV), a member of the genus Orthopneumovirus in the family Pneumoviridae, is one of the most common pathogens that cause acute lower respiratory tract infections in young children worldwide. The infections in infants develop severe RSV symptoms and sometimes may be fatal.

The HRSV is a negative-sense, single-strand, enveloped RNA virus with 15.2 kb in length. The genome encodes 11 proteins, including eight structural proteins (NP, P, M, SH, G, F, M2-1, M2-2, and L protein) and two nonstructural proteins (NS1 and NS2). According to antigenic differences in the G protein, the HRSVs are classified into two subtypes: HRSV-A and HRSV-B, which are further classified into 9 genotypes and 32 genotypes, respectively. Three RSV surface proteins including small hydrophobic protein, attachment glycoprotein, and fusion protein play an important role in humoral immune responses, neutralizing antibody development, and vaccine development.