Anti-Human Gammaherpesvirus Drug Discovery Products

Human gammaherpesvirus (HHV) is a double-stranded DNA (dsDNA) virus in the Herpesviridae family. There are two types of human gammaherpesvirus.

Epstein-Barr virus (EBV, HHV-4) is a major cause of infectious mononucleosis and is also associated with several types of cancer including Burkitt's lymphoma, Hodgkin's lymphoma, and nasopharyngeal carcinoma, especially in immunocompromised individuals. The virus targets the B lymphocytes of the immune system and is able to evade immune detection by expressing proteins that resemble human host proteins, making it difficult for the immune system to recognize and clear the virus. The genome consists of two main regions including the long (L) and the short (S) region. The L region encodes the viral tegument proteins and the S region encodes the major capsid protein, the viral surface glycoproteins, and other genes involved in immune evasion and replication.

Kaposi's sarcoma-associated herpesvirus (KSHV, HHV-8) is associated with the development of Kaposi's sarcoma, as well as primary effusion lymphoma and multicentric Castleman's disease. The virus is primarily transmitted through saliva, and sexual contact has also been identified as a potential route of transmission. The genome contains a unique long (U1) region, a unique short (U2) region, and a repeat (R) region. The U1 region encodes genes involved in DNA replication, recombination, and transcription regulation, while the U2 region encodes genes involved in host-cell interactions and immune evasion. The R region encodes several copies of the latency-associated nuclear antigen (LANA), which is responsible for maintaining the episomal state of the virus genome in infected cells.

At Creative Biolabs, we provide both anti-EBV and anti-KSHV antibody and probe products for researchers to study this important human gammaherpesvirus.