After a novel antibody is obtained, it may be engineered to enhance its functionality, such as isotype switching, chimerization, humanization and so on. Creative Biolabs is a leading service provider that focuses on antibody engineering for research, diagnostic and therapeutic applications. Our service portfolio includes functional engineering services, constructional engineering services and other antibody specialization and modification services.
Our antibody engineering team provides independent, custom service packages including antibody reformatting and production, epitope binning and mapping, antibody humanization, affinity maturation, affinity measurement, sequence liability identification, immunogenicity prediction, therapeutic developability assessment, and many other antibody specialization and modification services. Creative Biolabs is dedicated to accelerating virology antibody development projects to help our clients win the race in virology researches. The goal of antibody engineering is to combine various antibody domains to generate customized antibodies that show specialized binding properties, optimal half-lives and desirable effector functions. Our antibody engineering services are summarized as below.
Offer multiple different antibody formats, Fab, F(ab)'2, scFv, VHH, minibodies, etc.
Identify the epitope of an antibody and elucidate the mechanism of binding for an antibody.
Utilize a variety of methods and toolkits in the antibody humanization process.
Help clients to determine the kinetic properties of antibody-antigen interactions.
Combine molecular evolution and high-throughput phage library construction and screening.
Perform in vitro screening, in vivo screening and in silico assessment by SIAT platforms.
Select liability-free antibodies for further development and reduce cost by foreseeing risks.
Evaluate the candidates' drug-like manufacturability, physicochemical properties, and safety profiles.
Creative Biolabs has focused on the antibody engineering field for decades and established a series of platforms. A wide range of formats are available, including IgG, Fab, scFv, and CARs for virology researches.
For the functional engineering services, we are expertised in Antibody Affinity Maturation, Antibody Stability Improvement, ADCC Enhanced Antibody, CDC Enhanced Antibody etc.
To ensure the best quality of our antibody and protein engineering service, including the highest purity of the product and the lowest risk of contamination, Creative Biolabs has developed several platforms supported by our recombinant protein engineering scientists. In addition, we also have quality control lab, molecular biology lab, etc. Antibody engineering has become a well-developed discipline, encompassing discovery methods, production strategies, and modification techniques that have brought forth clinically investigated and marketed therapeutics.
Creative Biolabs is committed to providing high-quality services to promote the development of antibody affinity maturation, antibody stability improvement, chimeric antigen receptor (CAR) construction, single domain antibody generation, scFv/Fab construction and other antibody specialization and modification services. Also, we provide ViroAntibody discovery, ViroAntibody customized services. Please refer to each section for more information and contact us for a deep conversation to discuss how we can be involved in your viroantibody engineering development projects.