Antibody-dependent enhancement (ADE), also known as antibody-mediated (infection) intensification, is a risk that should be considered in vaccine development. Creative Biolabs' scientists provide the experience, technique, and expertise to advance your vaccine research as a world-leading provider of virology testing. We can create complex and customized assays to meet your exact specifications.
ADE is a phenomenon in which a virus's binding to suboptimal antibodies promotes its entry into host cells. If these cells (usually macrophages) allow viral replication, the antibodies will boost infection by increasing virus entry. Antibodies in ADE promote viral infection of target immune cells via the phagocytic FcR or complement pathway. ADE has been linked to mosquito-borne flavivirus infections like dengue and Zika. Because ADE is dependent on antibody concentration and neutralization ability, it is critical to assess the impact of an immunization regime's antibody response on ADE.
Fig.1 Antibody-mediated neutralization and ADE. (Arvin, et al., 2020)
ADE assays are a valuable tool for assessing antibodies' ability to enhance secondary infection with related viruses such as SARS-COV-2 and provide valuable insights into virus pathogenesis in the development of vaccines. At Creative Biolabs, we offer a variety of ADE assays.
Fig.2 The workflow of ADE assays. (Creative Biolabs)
Creative Biolabs can provide high-quality ADE assays to meet your needs by combining our virology capabilities and extensive expertise. We can conduct the studies you require on the viruses of your choice, such as SARS-COV-2, DENV, and Zika. Our integrated services and efficient workflow help you complete projects faster. Contact us today to learn more about our virology testing services.
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