Measles Virus (MeV)

Measles Virus (MeV) Antibody Products by Targets

MeV Background

Measles virus (MeV) is a single-stranded, negative-sense, enveloped, non-segmented RNA virus in the Morbillivirus genus of the Paramyxoviridae family. It was first isolated in a primary culture of human kidney cells from a measles patient. MeVs cause Measles, an acute viral illness that has been reported to be highly contagious and widespread. The MeV is directly responsible for over 100,000 deaths each year. Measles has been dramatically reduced due to vaccination. The measles vaccine is at least 95% effective, with close to 100% seroconversion rates. Children are the primary targets of MeV in the absence of vaccination.

Structure of MeV

The measles virus is a nonsegmented, single-stranded, negative-sense RNA virus with a length of approximately 16,000 nucleotides. The virion is spherical, with a diameter ranging from 100 to 300 nm. The nucleocapsid (N) protein, phosphoprotein (P), matrix (M) protein, fusion (F) protein, haemagglutinin (H) protein, and large (L) protein are all encoded by six genes in the genome. H and F proteins are involved in viral entry into the host cell and are important in pathogenesis. In general, the M protein ensures the integrity of viral particles. In general, the M protein ensures the integrity of viral particles. In addition, the viral genome encodes two non-structural proteins, C and V. These non-structural proteins aid the virus in evading the host immune system.

MeV Life Cycle

At the virus's surface, both the H and F transmembrane glycoproteins are visible. The H protein is in charge of receptor binding to the host cell, whereas the F protein is in charge of membrane fusions. The negative-stranded RNP is introduced into the cytoplasm following membrane fusions. Viral RNA is translated into viral proteins after being transcribed into mRNA. Viral glycoproteins mature as they travel to the cell surface. To complete the replication cycle, viral proteins assemble at the cell surface and new virion buds from the plasma membrane.

Fig.2 MeV replication cycle. (Ferren, et al., 2019)

Creative Biolabs, an antibody expert, now offers a wide range of anti-MeV antibody products for a variety of applications, many species, and in both conjugated and unconjugated forms. We also provide customized antibody development services including antibody discovery, engineering, customized services and neutralization assays. If you are interested in our products or services, please feel free to contact us for more details.

References

1. Aref, S.; et al. A. Measles to the rescue: a review of oncolytic measles virus. Viruses. 2016, 8(10): 294.
2. Ferren, M.; et al. Measles encephalitis: towards new therapeutics. Viruses. 2019, 11(11): 1017.