Fig.1 Schematic diagram of the HMPV particle. (Panda, et al., 2014)(Sánchez-Paz, 2010)
Human metapneumovirus (HMPV) belongs to the Pneumoviridae family and Metapneumovirus genus. HMPV is a negative-sense single-stranded RNA virus and is pleomorphic in nature and its size varies from 150 nm to 600 nm. It is a ubiquitous respiratory pathogen that has been circulating in human populations undetected for decades until hMPV was isolated in 2001. Since then, hMPV has been detected in 4-16% of patients with acute respiratory tract infection (ARI). Globally, HMPV is recognized as the second most common cause of bronchiolitis and pneumonia in children <5 years of age. As a leading virology antibody provider, Creative Biolabs offers various series of virology antibody services, such as discovery, development, and customized services to help our customers achieve their research goals.
Based on monoclonal-antibody studies and the sequencing of multiple genes, hMPV exists as two genotypes, A and B, that are further subdivided into lineages A1, A2, B1, and B2. Subgroup A2 is again subdivided into A2a and A2b.
The attachment glycoprotein (G), fusion protein (F) and small hydrophobic protein (SH) of the virus protrude out on the virion surface while matrix protein (M) lines the inner surface of the lipid bilayer envelope. The nucleoprotein (N), Phosphoprotein (P) and RNA-dependent RNA polymerase (L) wraps the negative-sense single-stranded RNA genome in the viral core and constitute the ribonucleoprotein (RNAP) complex. HMPV G is capable of binding cell surface GAGs and may contribute to virus attachment. HMPV F is necessary and sufficient for membrane fusion and capable of mediating entry without an additional attachment protein. The proteins matrix 2 proteins, M2-1 and M2-2, are expressed only during the replicative viral cycle. G, M2-1, M2-2 and SH proteins may be involved in the evasion of the immune response.
Fig.2 Schematic illustration of the structure of the HMPV ssRNA genome and HMPV particle. (Céspedes, et al., 2016)
Creative Biolabs now provides numerous HMPV antibodies targeting various proteins such as F, G, M2, SH, P, etc. We also provide fully comprehensive services including ViroAntibody Neutralization Assays, antibody discovery, engineering, and customized services. Please feel free to contact us for further information.