Fig.1 Structure of CMV.
Fig.2 Cytomegalovirus life cycle.
Cytomegalovirus (CMV) is a popular viral pathogen found throughout the world, and humans and monkeys are its natural hosts. It is associated with viruses that cause chickenpox and infectious mononucleosis (mononuclear). CMV is spread mainly through close contact with someone who already has CMV. It can be spread through body fluids including saliva, blood and urine.
Fig.3 Illustration of CMV.
In the Herpesviridae family, CMV belongs to the Betaherpesvirinae subfamily, and also includes the genus Muromegalovirus and Roseolovirus. It is also associated with other herpes viruses in the Alphaherpesvirinae subfamily, including herpes simplex virus 1 and 2 and varicella-zoster virus, and the Gammaherpesvirinae subfamily, which includes Epstein-Barr virus and Kaposi's sarcoma-associated herpesvirus.
Several species of CMV have been identified and classified for different mammals. The most studied is human CMV (HCMV), also known as human betaherpes virus 5 (HHV-5). Other primate CMV species include chimpanzee CMV (CCMV) infected with chimpanzees and orangutans, as well as simian CMV (SCCMV) and rhesus monkey CMV (RhCMV) infected with macaques.
The CMV genome is linear and nonsegmented and consists of approximately 230,000 bp double-stranded DNA. The viruses in the CMV are enveloped and surrounded by an icosahedral capsid (100-110 nm in diameter, 162 capsids), with spherical to polymorphic and circular geometry, and T = 16 symmetry. The diameter is about 150-200 nm. Between the capsid and the viral envelope is a layer of protein called the tegument. The virus envelope is derived from the cell membrane, and at least two different viral glycoproteins are embedded in the lipid bilayer.
Most patients with acute CMV develop recessive infections. Once the CMV enters the human body, it will survive in the human body permanently. Like other herpes viruses, CMV lurks in the host. Most patients with CMV will not get sick and do not know they are infected. When the host's immune system is damaged, it will reactivate and fall off, and may cause serious illness. Primary CMV infection will cause up to 7% of mononucleosis cases, and will show symptoms that are almost indistinguishable from those caused by Epstein-Barr virus. In addition to newborns, people with strong immunity have fewer complications of acute CMV infection. In the United States, 50% to 80% of adults are infected with CMV before the age of 40.
Creative Biolabs provides a large number of CMV antibodies against various targets to meet customer goals. In addition, we also provide personalized solutions, including ViroAntibody discovery, ViroAntibody engineering, ViroAntibody customized and ViroAntibody neutralization assays services to help you produce specific antibodies and maximize the success of the project. If you have any requirements for CMV antibodies, whether it is an off-the-shelf product or a special customized product, you can contact us at any time for more details.