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Cat#: VRS-0124-YT5247
Lenti-MBGV GP Pseudovirus [Luciferase, HIV-1 Packaging System]
MBGV GP Pseudovirus is produced by cotransfecting 293T cells with the mammalian expression vector pCMV4neo encoding MBGV GP protein and HIV-1 NL4-3 carrying a luciferase reporter gene. Pseudovirus-containing supernatant was harvested 24 h following transfection. The supernatant was cleared of cell debris by centrifugation and filtered through a 0.45-μm-pore-size filter. The produced pseudoviruses carry MBGV GP proteins, which is a powerful tool for MBGV vaccine and entry inhibitor research.
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- Product Summary
- Packaging, Storage & Formulations
- Target Details
Product Summary
| Type : | Pseudovirus |
| Virus Name : | Marburg Virus |
| Virus Packaging Protein : | GP |
| Packaging System : | HIV-1 Packaging System |
| Packaging Cell : | 293T |
| Reporter Gene : | Luciferase |
| Titer : | >1x 108 virus copies/mL |
| Application Notes : | The pseudovirus can be usd for the following applications: 1. Antibody neutralization assay, Serum neutralization assay. 2. As virus standard alternative in diagnostic assay or others. 3. Drug screening including vaccine development, viral entry inhibitor development. 4. As a safe virology tool to discover the virus entry mechanisms. |
Packaging, Storage & Formulations
| Form : | Liquid |
| Storage : | Store at -80°C and stable for 6 months from the date of shipment, avoiding freeze/thaw cycles. |
| Shipping : | Dry ice |
| Note : | The pseudovirus can be used under BSL-2 conditions. Please reach out to our scientists for detailed instructions or guidelines of the pseudovirus. |
Target Details
| Introduction : | Marburg viruses (MBGV) are enveloped, single negative-stranded RNA viruses belonging to the family Filoviridae. The viruses are the most deadly human-disease-causing agents (biosafety level-4 pathogens ). MBGV infection in humans is often associated with severe hemorrhagic fever and high mortality. MBGV contains a transmembrane glycoprotein (GP) which is heavily glycosylated with both N-linked carbohydrates (including high-mannose oligosaccharides) and O-linked carbohydrates. GP forms the trimeric spikes that occupy the entire surface of the virion. It is responsible for cellular binding and fusion. Therefore, GP is a key target for preventing MBGV infections. Ssubstances that directly interact with GP might interfere with filovirus infection by preventing viral entry into and/or fusion with the target cells. |
| Alternative Names : | GP; MARV GP; MARV_gp4 |
| Gene ID : | 920945 |
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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