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Cat#: VRS-0124-YT5267
Lenti-HCV E1 and E2 Pseudovirus [GFP, MLV Packaging System]
Lenti-HCV E1 Pseudovirus is produced by transfecting 293T cells with MLV CMV-gag-pol, MLV-GFP, and the plasmids expressing HCV E1 and E2 proteins. Pseudovirus-containing supernatant was harvested 48 h following transfection. The supernatant was cleared of cell debris by centrifugation and filtered through a 0.45-μm-pore-size filter. The produced pseudoviruses carrying HCV E1 and E2 proteins is a powerful tool for studying mechanism of virus entry, antiviral mechanism, neutralization antibody assay, and screening antivirus inhibitor.
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- Product Summary
- Packaging, Storage & Formulations
- Target Details
Product Summary
| Type : | Pseudovirus |
| Virus Name : | Hepatitis C Virus |
| Virus Packaging Protein : | E1 and E2 |
| Packaging System : | MLV Packaging System |
| Packaging Cell : | 293T |
| Reporter Gene : | GFP |
| Titer : | >1x 108 virus copies/mL |
| Application Notes : | The pseudovirus can be usd for the following applications: 1. Antibody neutralization assay, Serum neutralization assay. 2. As virus standard alternative in diagnostic assay or others. 3. Drug screening including vaccine development, viral entry inhibitor development. 4. As a safe virology tool to discover the virus entry mechanisms. |
Packaging, Storage & Formulations
| Form : | Liquid |
| Storage : | Store at -80°C and stable for 6 months from the date of shipment, avoiding freeze/thaw cycles. |
| Shipping : | Dry ice |
| Note : | The pseudovirus can be used under BSL-2 conditions. Please reach out to our scientists for detailed instructions or guidelines of the pseudovirus. |
Target Details
| Introduction : | Hepatitis C virus (HCV) is the most important causative agent of posttransfusion and sporadic non-A non-B hepatitis, infecting more than 200 million people worldwide. HCV infection becomes chronic in most cases and may eventually result in hepatitis, liver cirrhosis, and hepatocellular carcinoma. The HCV genome encodes two envelope glycoproteins (E1 and E2), which are thought to be responsible for receptor binding and membrane fusion resulting in virus penetration. |
| Alternative Names : | HCV E1 and E2; Envelope glycoprotein; Structural polyprotein |
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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