Porcine Hemagglutinating Encephalomyelitis virus (PHEV)
The porcine hemagglutinating encephalomyelitis virus (PHEV) is a highly neurotropic virus that infects pigs and causes neurological and/or digestive disease. Serological studies indicate that PHEV is widespread, wreaking havoc on animal welfare and economic performance. Creative Biolabs is proud to supply comprehensive, quality-assured antibodies for all veterinary species as an antibody expert. With extensive experience in virology research, our expert team is confident in providing off-the-shelf anti-PHEV antibody products and customized services to clients all over the world.
Background
PHEV is not zoonotic and does not infect pigs. This virus can infiltrate the central nervous system (CNS) and cause neurological dysfunction in susceptible animals such as pigs, mice, and rats. PHEV is the only known neurotropic coronavirus affecting pigs and one of the first swine coronaviruses to be isolated. It was derived from bovine CoV. PHEV has only one serotype and several strains that are all serologically crossreactive. The first clinical outbreak in swine herds in Canada was reported in 1957, and the virus was isolated in 1961 and classified as a coronavirus in 1971. and poses no threat to human public health.
PEDV Genome and Proteins
PHEV is a member of the coronaviridae family and the genus betacoronavirus. PHEV is an enveloped virus that is roughly spherical in shape and has a linear, capped, polyadenylated, single-stranded, positive-polarity, non-segmented RNA genome. The replicase ORF, which encodes replicase polyproteins pp1a and pp1ab, a precursor for multiple nonstructural proteins, occupies the first two-thirds of the viral genome and is cleaved into 16 nonstructural proteins (nsp1-16). The viral genome's remaining one-third 3' region encodes five structural proteins: small envelope (E), membrane (M), nucleocapsid (N), spike (S), and hemagglutinin-esterase protein (HE), as well as three non-structural proteins (NS2A, NS4.9, and NS12.7).
S protein is a large, multifunctional protein that forms large petal-shaped spikes on the surface of virions and contains antigenic determinants that activate the immune response, causing antibodies to be produced that neutralize virus infectivity. The M protein, as the most abundant structural envelope protein, contributes to the virion's shape. The HE protein acts as a receptor-destructive enzyme.
Fig.1 PHEV/2008 genome. (Shi, et al., 2018)
Anti-PHEV Antibodies
Creative Biolabs now specializes in the development of antibodies for veterinary immune research. Anti-PHEV antibodies are available in a variety of applications, species, and conjugated and unconjugated forms. These antibodies have been rigorously tested to ensure their purity and quality to expedite your research process. We also offer customized antibody development services, such as antibody discovery, engineering, and customized services, for special needs. As a client, you have the freedom to select the services you require. Please do not hesitate to contact us.
To begin your research, browse our entire catalog of PHEV antibodies.
References
- Shi, J.; et al. Genomic characterization and pathogenicity of a porcine hemagglutinating encephalomyelitis virus strain isolated in China. Virus genes. 2018, 54(5): 672-683.
- Mora-Díaz, J.C.; et al. Porcine hemagglutinating encephalomyelitis virus: a review. Frontiers in veterinary science. 2019, 6: 53.
