Fig.1 Schematic of a LCMV virion. (Radoshitzky, et al., 2015)
The Arenaviridae family includes the lymphocytic choriomeningitis mammarenavirus (LCMV), which is found on the American, Asian, and European continents. It can cause serious neurological issues such as meningitis, encephalitis, and neurologic birth defects. The majority of rodents are susceptible to LCMV. The virus's natural host and reservoir is the common house mouse, Mus musculus. Choriomeningitis develops in adult mice after infection. Hamsters are particularly susceptible to infection, whereas rats are naturally resistant. LCMV is a zoonotic virus. LCMV can be transmitted to humans through direct contact with infected rodent body fluids. LCMV rarely causes choriomeningitis in humans. LCMV infection is usually not fatal, and the vast majority of patients who develop aseptic meningitis or encephalitis as a result of LCMV infection survive.
The LCMV virus is a single-stranded RNA virus with a bipartite genome. Virions have dense lipid envelopes and are spherical or pleomorphic in shape, measuring 50-300 nm in diameter. The LCMV genome is made up of two negative-sense single-stranded RNA segments, e long (L) and small (S), with approximate sizes of 7.2 and 3.4 kb. The L segment encodes a zinc-binding matrix protein and a viral RNA-dependent RNA polymerase (L) (Z). The nucleoprotein (NP) and viral glycoprotein complex (GPC) precursors encoded by the S segment are posttranslationally cleaved into two mature virion glycoproteins, GP1 and GP2, which form the spikes that decorate the virion's surface. GP1 is in charge of receptor engagement, while GP2 is in charge of membrane fusion.
Fig.2 Schematic of LCMV particle and genome. (Lapošová, et al., 2013)
The LCMV virus can be grown in several cell lines, including BHK-21, L-929, and Vero cells. This virus has long been used as a model system for studying viral immunology, persistent infection, and pathogenesis. It is a noncytolytic virus, and the majority of diseases caused by LCMV infection in mice are caused by innate and acquired immune responses. The LCMV mouse model is now a fundamental in vivo research tool in immunology, helping to understand the key principles of both innate and specific immunity. Furthermore, the LCMV model represents a significant step forward in cancer research.
Creative Biolabs offers a wide range of antibodies for veterinary and animal research. We provide anti-LCMV antibodies for a variety of hot targets such as GPC, GP1, GP2, and others. We also offer customized antibody development services for anti-LCMV antibodies, including antibody discovery, engineering, and customized services. Please contact us if you require any additional information.
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