Feline Parvovirus (FPV)
Introduction
Feline parvovirus (FPV), also known as feline panleukopenia virus, is a viral disease that can be highly contagious and even fatal in cats. Feline panleukopenia, feline infectious enteritis (FIE), and feline distemper are all names for this disease. Domestic cats and other Felidae, as well as species from the Mustelidae, Procyonidae, and Viverridae families, are infected by this virus (including raccoons, ring-tailed cats, foxes and minks). Furthermore, canine parvovirus-2 variants (CPV-2a, CPV-2b, and CPV-2c) can infect cats and are the cause of feline panleukopenia. Parvoviruses are particularly dangerous because they can survive in the environment for long periods of time (up to several years) and are resistant to many disinfectants. It is now a rare disease, thanks in large part to the availability and use of highly effective vaccines. Creative Biolabs, a virology antibody expert, offers viroantibody products that target veterinary markers. We are now pleased to offer anti-FPV antibody products to further FPV research.
FPV Structure
FPV is a small, non-enveloped single-stranded DNA virus with a diameter of 20-24 nm. The genome is about 5123nt long and contains four open reading frames. ORF1 and 2 encode non-structural proteins (NS1 and NS2), while ORF3 and 4 encode structural viral proteins (VP1 and VP2). NS1 is involved in virus replication, transcription, and apoptosis in host cells. NS2 regulates the assembly and translation of capsid proteins. The VP2 protein is a major capsid component that is important for viral pathogenicity as well as host immune response.
Fig.1 Genetic differences in FPV in dogs from Italy and Egypt. (Diakoudi, 2022)
FPV vs CPV
Both the FPV and the CPV belong to the Parvovirinae subfamily of the Parvoviridae. For the first time, FPV was isolated in 1965. It was discovered in 1977 that CPV-2 evolved from FPV by crossing species barriers and acquiring five or six amino acid changes in the capsid protein gene. FPV and CPV are antigenically and genetically related (~98% identity at the nucleotide level), but differ in host range and pathogenicity. CPV-2 variants, on the other hand, can bind to canid cellular receptors and infect cats. Furthermore, CPV and FPV coinfections have been reported in cats with clinical disease.
Antibodies to FPV
Creative Biolabs is the leading antibody supplier to customers worldwide for veterinary immune system research. Our scientists have years of experience creating custom monoclonal and polyclonal antibodies. We provide anti-FPV antibodies for hot targets to help you further your feline panleukopenia research. We also provide antibody discovery, engineering, and customized services for FPV antibodies. Please contact us to discuss your project.
To begin your research, browse our entire catalog of FPV antibodies.
Reference
- Diakoudi, G.; et al. Feline Panleukopenia Virus in Dogs from Italy and Egypt. Emerging infectious diseases. 2022, 28(9): 1933-1935.
