Canine parainfluenza virus (CPIV), also known as Canine morbillivirus, is a highly contagious disease that affects both wild and domestic Canidae. It causes a variety of symptoms affecting the respiratory, gastrointestinal, and central nervous systems. CPIV is primarily transmitted via aerosols, but it can also be spread through direct and indirect contact with infected secretions. CPIV was discovered in the 1730s. The introduction and widespread use of CPIV vaccines in the 1950s greatly aided in keeping the disease under control. CDV remains endemic in many parts of the world, despite widespread vaccination. Creative Biolabs is pleased to provide anti-CPIV antibodies to meet your requirements as an antibody expert.
CPIV Structure
CPIV is an enveloped RNA virus in the genus Rubulavirus of the family Paramyxoviridae. Its genome is a negative nonsegmented single-stranded RNA with sizes ranging between 15 and 19kb. The nucleocapsid protein (NP), V protein (V), phosphoprotein (P), matrix protein (M), fusion protein (F), small hydrophobic protein (SH), hemagglutinin-neuraminidase (HN), and RNA polymerase large protein are all encoded by seven genes (L). The V/P gene encodes both the V and P proteins, which are found in the same genomic region. The glycosylated HN and F proteins form spikes that protrude through the virus envelope. HN glycoprotein neuraminidase activity is required for virus release from host cells. The V protein is involved in both the evasion of host immune responses and the regulation of viral RNA synthesis.
Fig.1 CPIV structure (Lamb, et al., 2005); and Genome organization (Chen, 2018).
Host Range
PIV-5 has been shown to infect and cause respiratory disease in a variety of hosts. For decades, the name and host range of PIV-5 have been misunderstood. Because the virus was discovered in cultures of rhesus and cynomolgus monkey kidney cells, it was given the name simian virus 5. (SV5). CPIV-5 was initially known as CPIV-2 because it caused a respiratory disease similar to human PIV-2. CPIV used to affect only horses, but it is now thought to have jumped species and adapted to cause illness in dogs. It is now thought to be a virus that only affects dogs. It can also be transmitted from cats to dogs and vice versa, as well as from dogs to humans with compromised immune systems.
Antibodies to CPIV
Creative Biolabs provides antibodies to customers worldwide for veterinary immune system research. We provide anti-CPIV antibodies for hot targets to meet the demands of your research. We also offer customized antibody development services for CPIV antibodies, including antibody discovery, engineering, and customized services. All antibodies have been validated in a variety of research applications and with samples derived from a variety of different species. For more information, please contact us.
To begin your research, browse our entire catalog of CPIV antibodies.
References
- Chen, Z. Parainfluenza virus 5-vectored vaccines against human and animal infectious diseases. Reviews in medical virology. 2018, 28(2): e1965.
- Lamb, R.; et al. T The negative sense single stranded RNA viruses. Virus taxonomy. Eighth report of the International Committee on Taxonomy of Viruses. Elsevier Academic Press, San Diego, CA. 2005: 607-738.
