Canine Distemper Virus (CDV)

Canine Distemper Virus (CDV) Antibody Products by Targets

Introduction

Canine distemper virus (CDV), also known as Canine morbillivirus, is a highly contagious disease that affects both wild and domestic Canidae. It causes a variety of symptoms affecting the respiratory, gastrointestinal, and central nervous systems. The first case of canine distemper was reported in the 1730s. CDV has only one serotype and numerous strains that differ in tissue tropism and pathogenicity. The introduction and widespread use of CDV vaccines in the 1950s greatly aided in keeping the disease under control. CDV remains endemic in many parts of the world, despite widespread vaccination.

CDV Structure

CDV belongs to the Morbillivirus genus and the Paramyxoviridae family. CDV particles are pleomorphic, enveloped virions with a diameter of about 150 nm that are frequently spherical. Its genome is a 15.7 kb negative-sense single-stranded RNA molecule that encodes six structural proteins known as nucleocapsid (N), phosphoprotein (P), matrix (M), fusion (F), hemagglutinin (H), and large Polymerase (L), as well as two non-structural proteins (C and V). The F and H proteins, which are found in the lipid envelope surrounding the virion, are responsible for virus recognition and entry into the host cell. Because of their high genetic variation, the H and F genes are ideal targets for genotype identification and strain analysis. The N protein encapsulates and protects the RNA, and it is linked to the P and L proteins, which help with transcription and replication.

Fig.2 Genome organization. (Rendon-Marin, et al., 2019)

Host Range

It is recognized as a multi-host pathogen on a global scale. CDV is highly susceptible to cross-species transmission among domestic and wildlife reservoir hosts, which is a significant source of emerging and endemic diseases. All animals in the Canidae, Mustelidae, and Procyonidae families are susceptible to CDV infection. Recent large outbreaks in nonhuman primates indicate that the virus has adapted to these animals and that it has the potential to infect humans. There have been no reports of CDV infecting humans.

Fig.3 Schematic representation of the possible CDV evolutionary transmission route. (Quintero-Gil, et al., 2019)

Antibodies Targeting CDV

Creative Biolabs is proud to offer the most comprehensive portfolio of highly validated antibodies for veterinary immune system research. To meet the needs of our customers, we offer a variety of monoclonal and polyclonal anti-CDV antibodies for hot targets. We also offer customized antibody development services for anti-CDV antibodies, including antibody discovery, engineering, and customized services. Our antibodies and proteins are rigorously tested to ensure purity and quality, allowing you to complete your research faster. Please contact us for more information, a quote, or to set up a teleconference.

To begin your research, browse our entire catalog of CDV antibodies.

References

1. da Costa, V.G.; et al. First complete genome sequence and molecular characterization of Canine morbillivirus isolated in Central Brazil. Scientific reports. 2021, 11(1): 1-10.
2. Rendon-Marin S.; et al. Tropism and molecular pathogenesis of canine distemper virus. Virology journal. 2019, 16(1): 1-15.
3. Quintero-Gil, C.; et al. Origin of Canine Distemper Virus: Consolidating evidence to understand potential zoonoses. Frontiers in Microbiology. 2019, 10: 1982.