Creative Biolabs is excited to greet you at the upcoming international conferences. Meet our team at the 13th Annual World ADC San Diego and the 13th Annual World Multispecific Summit in September (booth number to be updated) for expert consultation on your drug discovery. Shoot an email to arrange an in-person meeting!
Antibodies (by target):
Infectious virus can interact with specific receptor, resulting virus entry into host cells. For example, SARS-CoV-2 consists of four structural proteins, including S (spike), E (envelope), M (membrane), and N (nucleocapsid) proteins. S, M and E proteins create the viral envelope together, and N protein holds the SARS-CoV-2 RNA genome. As a key component, spike (S) was identified as the protein responsible for virus entry into human cells. In addition, many articles propose and validate that the angiotensin converting enzyme 2 (ACE2) might be the SARS-CoV-2 infection receptor, and spike/ACE2 interaction might be the mechanism of host cell entry. To facilitate the virus in vitro assays, pseudohost is developed which is a stable cell line expressing the specific receptor, such as human angiotensin-converting enzyme 2 (hACE2) etc. Creative Biolabs developed hACE2 overexpressed 293T and CHO stable cell lines to advance your COVID-19 researches. Together with our pseudovirus, pseudohost can be used in the following applications.
Fig.1 Structural and functional basis of SARS-CoV-2 entry by using human ACE2. (Wang, 2020)