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Cat#: VRS-1223-YT2
ViroAb™ Mouse Anti-ACNV VNN Monoclonal Antibody (XX0742)
This Mouse Monoclonal antibody is specific for VNN protein. The antibody can be used for applications: IHC. The antibody is for research use only and is not approved for use in humans or clinical diagnosis.
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- Target Published Figures
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Histological sections of the brain from Atlantic cod with viral nervous necrosis without clinical signs of disease, stained with haematoxylin and eosin (c-d) and immunohistochemistry for nodavirus (a-b).
(a) Immunopositive cells (red) of unknown nature (×) adjacent to neurons (arrowhead) and a blood vessel (arrow). At right two neurons without immunostaining and without adjacent immunopositive cells. (b) Aggregate with immunopositive macrophage-like cells and intra- or extracellular vacuoles. (c) Cerebellum. Aggregation in the Purkinje cell layer of macrophage-like cells that are immunopositive. (d-e) The same cluster of concentric organized macrophage-like cells in the Purkinje-cell layer. (d) Note also prominent blood vessels. (e) Immunostaining of cytoplasm (apparently in all the cells).
- Product Overview
- Product Properties
- Packaging, Storage & Formulations
- Applications
Product Overview
| Specificity : | This antibody reacts with VNN of Atlantic cod nodavirus. |
| Clone : | XX0742 |
| Host Species : | Mouse |
| Antibody Isotype : | IgG2a |
| Species Reactivity : | Nodavirus |
Product Properties
| Purity : | >95% as determined by SDS-PAGE |
| Concentration : | Lot specific |
Packaging, Storage & Formulations
| Form : | Lyophilized powder |
| Formulation : | PBS (pH 7.2) |
| Storage : | Store at 4°C for short term. Store at -20°C for long term. Avoid repeated freeze/thaw cycles. Refer to the COA file for specifics. |
Applications
| Application : | IHC |
| Application Notes : | The optimal working dilutions should be determined by the end user. |
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Gjessing, M. C., et al. "Nodavirus provokes subclinical encephalitis and retinochoroiditis in adult farmed Atlantic cod, Gadus morhua L." Journal of fish diseases 32.5 (2009): 421-431.
Virology-
(Verified Customer)
I ordered the Mouse Anti-Atlantic Cod Nodavirus VNN antibody and will test it in immunohistochemistry analysis with histological sections of the brain from Atlantic cod. Hope it will work well.
Dear sir,
We're interested in your product "VRSX-0823-YT2001". Is this product in stock? If not, how long is the delivery time?
Regards,
Bobby
Thank you for contacting us. The lead time of this product is about 1-2 weeks. Please don't hesitate to contact us if you need any further advice or information on other aspects.
Target Research Highlights
Viral nervous necrosis (VNN) caused by betanodavirus affects many species of farmed marine fish, in particular juveniles. Nodavirus-provoked cell death and inflammation were detected in eye and brain, particularly in the retina and cerebellum of Atlantic cod during clinical stages of VNN. Virus was detected both by PCR and immunohistochemistry. Macroscopic examination allows only the detection of a dilated swim bladder, which is not specific to VNN. RPE cells dominate the initial reactive response as additional mononuclear inflammatory cells were seen in retina and choroid in areas that did not stain for nodavirus by IHC. The apparently increased numbers of prominent vessels, proliferation of cells in cords and a thinner molecular layer also indicate chronic changes in these cod. The study about Atlantic Cod Nodavirus VNN may help reveal the pathogenesis of this disease, including the development and possible regeneration of the brain and eye lesions.
References
Gjessing, M. C., et al. "Nodavirus provokes subclinical encephalitis and retinochoroiditis in adult farmed Atlantic cod, Gadus morhua L." Journal of fish diseases 32.5 (2009): 421-431.
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