SARS-CoV-2

Antibodies (by target):

SARS-CoV-2 Antibody Products by Targets

SARS-CoV2 genome, transcriptome. Fig.1 SARS-CoV-2 genome, transcriptome.

The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Lifecycle. Fig.2 The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Lifecycle.

SARS-CoV-2 Background

Since last December, 2019, an outbreak of a novel coronavirus disease (COVID-19; previously known as 2019-nCoV) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was reported. COVID-19 has subsequently affected various global regions including Americas, Europe, Africa, Western Pacific etc. Even though COVID-19 is an acute resolved disease, it can also be deadly, with a 2% case fatality rate. As of Apr 14, about 1,844,863 cases has been confirmed globally, with 117,021 death cases. Now COVID-19 is an emerging, rapidly evolving situation, and has become a pandemic.

Illustration of a SARS-CoV-2 virion.Fig.3 Illustration of a SARS-CoV-2 virion.

Transmission electron micrograph of SARS-CoV-2 virions. Fig.4 Transmission electron micrograph of SARS-CoV-2 virions.

Virus Classification of SARS-CoV-2

SARS-CoV-2 is a positive-sense single-stranded RNA virus, and it’s a strain of severe acute respiratory syndrome-related coronavirus (SARSr-CoV). Coronaviruses consist of four genus: α, β, γ, and δ. The coronaviruses that infect mammals are mainly α and β genus. Among the viruses capable of infecting humans, HCoV-229E and HCoV-NL63 belong to the α coronavirus, and HCoV-OC43, SARS-CoV, HCoV-HKU1, MERS-CoV, and SARS-CoV-2 belong to the β coronavirus.

SARS-CoV-2
Virus family Coronaviridae
Virus genus Betacoronavirus
Virus subgenus Sarbecovirus
Virus species Severe acute respiratory syndrome-related coronavirus
Virus strain Severe acute respiratory syndrome coronavirus 2

Table 1. SARS-CoV-2 classification.

Structure of SARS-CoV-2

SARS-CoV-2 was first sequenced by Fan Wu team, and the sequence was published in MN908947. SARS-CoV-2 consists of four structural proteins, including S (spike), E (envelope), M (membrane), and N (nucleocapsid) proteins. S, M and E proteins create the viral envelope together, and N protein holds the SARS-CoV-2 RNA genome. As an important envelope protein, S protein is identified as the protein responsible for virus entry into human cells. In addition, the angiotensin converting enzyme 2 (ACE2) has been demonstrated to be the receptor, and spike/ACE2 interaction might be the mechanism of cell entry.

SARS-CoV-2 Antibodies

Creative Biolabs now provides a variety of SARS-CoV-2 antibodies targeting various proteins (such as SARS-CoV-2 spike protein, SARS-CoV-2 nucleocapsid protein etc.) to meet our clients’ requirements. Please submit your specific SARS-CoV-2 antibody inquiry to us, and we will reply within several hours. For some targets, ready-to-use catalogue is not available. Please reach out to our scientists for antibody discovery services and customized services. For antibody related virology assays, please contact us for a specific assay service. We also provide a full comprehensive suite of secondary antibodies and isotype controls to meet your needs.

Target Proposed function ViroAntibodies
ORF 1a Encoded nonstructural proteins (nsp1 to nsp11), essential for viral replication, viral assembly, immune response modulation, etc. Learn more ViroAntibodies
ORF 1b Encoded nonstructural proteins (nsp12 to nsp16), essential for viral replication Learn ViroAntibody Discovery Services
S Spike protein, binding to cell receptor and mediate virus-cell fusion Learn more ViroAntibodies
ORF 3a Accessory protein Learn ViroAntibody Discovery Services
ORF 3b Accessory protein Learn ViroAntibody Discovery Services
E Envelope protein, virus assembly and morphogenesis Learn more ViroAntibodies
M Membrane protein, virus assembly Learn ViroAntibody Discovery Services
ORF6 Accessory protein Learn ViroAntibody Discovery Services
ORF 7a Accessory protein Learn more ViroAntibodies
ORF 7b Accessory protein Learn ViroAntibody Discovery Services
ORF8 Accessory protein Learn ViroAntibody Discovery Services
N Nucleocapsid protein, forms complexes with genomic RNA, interact with M protein for viral assembly Learn more ViroAntibodies
ORF 9a Accessory protein Learn ViroAntibody Discovery Services
ORF 9b Accessory protein Learn ViroAntibody Discovery Services
ORF 10 Accessory protein Learn ViroAntibody Discovery Services

The current provided SARS-CoV-2 antibody products are for research use only and are not approved for use in humans or in clinical diagnosis and therapeutics. If you are interested in SARS-CoV-2 antibody discovery and development services for in vitro diagnosis or therapeutic applications, please contact us for more details.

References

  1. Wu, Fan, et al. "A new coronavirus associated with human respiratory disease in China." Nature 579.7798 (2020): 265-269.
  2. Hoffmann, Markus, et al. "SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor." Cell (2020).
  3. Lu, Roujian, et al. "Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding." The Lancet 395.10224 (2020): 565-574.
  4. Kim D W, Lee J Y, Yang J S, et al. The Architecture of SARS-CoV-2 Transcriptome. Cell. 2020. 181, 4, 914-921.e10
  5. Chakravarty D, Nair S S, Hammouda N, et al. Sex differences in SARS-CoV-2 infection rates and the potential link to prostate cancer. Nature communications biology. 2020, 3, 374
All products and services are intended for Research Use Only, and NOT to be used in diagnostic or therapeutic procedures.

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