Fig.1 SARS-CoV-2 genome, transcriptome.
Fig.2 The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Lifecycle.
Since last December, 2019, an outbreak of a novel coronavirus disease (COVID-19; previously known as 2019-nCoV) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was reported. COVID-19 has subsequently affected various global regions including Americas, Europe, Africa, Western Pacific etc. Even though COVID-19 is an acute resolved disease, it can also be deadly, with a 2% case fatality rate. As of Apr 14, about 1,844,863 cases has been confirmed globally, with 117,021 death cases. Now COVID-19 is an emerging, rapidly evolving situation, and has become a pandemic.
Fig.3 Illustration of a SARS-CoV-2 virion.
Fig.4 Transmission electron micrograph of SARS-CoV-2 virions.
Virus Classification of SARS-CoV-2
SARS-CoV-2 is a positive-sense single-stranded RNA virus, and it’s a strain of severe acute respiratory syndrome-related coronavirus (SARSr-CoV). Coronaviruses consist of four genus: α, β, γ, and δ. The coronaviruses that infect mammals are mainly α and β genus. Among the viruses capable of infecting humans, HCoV-229E and HCoV-NL63 belong to the α coronavirus, and HCoV-OC43, SARS-CoV, HCoV-HKU1, MERS-CoV, and SARS-CoV-2 belong to the β coronavirus.
|Virus species||Severe acute respiratory syndrome-related coronavirus|
|Virus strain||Severe acute respiratory syndrome coronavirus 2|
Table 1. SARS-CoV-2 classification.
Structure of SARS-CoV-2
SARS-CoV-2 was first sequenced by Fan Wu team, and the sequence was published in MN908947. SARS-CoV-2 consists of four structural proteins, including S (spike), E (envelope), M (membrane), and N (nucleocapsid) proteins. S, M and E proteins create the viral envelope together, and N protein holds the SARS-CoV-2 RNA genome. As an important envelope protein, S protein is identified as the protein responsible for virus entry into human cells. In addition, the angiotensin converting enzyme 2 (ACE2) has been demonstrated to be the receptor, and spike/ACE2 interaction might be the mechanism of cell entry.
Creative Biolabs now provides a variety of SARS-CoV-2 antibodies targeting various proteins (such as SARS-CoV-2 spike protein, SARS-CoV-2 nucleocapsid protein etc.) to meet our clients’ requirements. Please submit your specific SARS-CoV-2 antibody inquiry to us, and we will reply within several hours. For some targets, ready-to-use catalogue is not available. Please reach out to our scientists for antibody discovery services and customized services. For antibody related virology assays, please contact us for a specific assay service. We also provide a full comprehensive suite of secondary antibodies and isotype controls to meet your needs.
|ORF 1a||Encoded nonstructural proteins (nsp1 to nsp11), essential for viral replication, viral assembly, immune response modulation, etc.||Learn more ViroAntibodies|
|ORF 1b||Encoded nonstructural proteins (nsp12 to nsp16), essential for viral replication||Learn ViroAntibody Discovery Services|
|S||Spike protein, binding to cell receptor and mediate virus-cell fusion||Learn more ViroAntibodies|
|ORF 3a||Accessory protein||Learn ViroAntibody Discovery Services|
|ORF 3b||Accessory protein||Learn ViroAntibody Discovery Services|
|E||Envelope protein, virus assembly and morphogenesis||Learn more ViroAntibodies|
|M||Membrane protein, virus assembly||Learn ViroAntibody Discovery Services|
|ORF6||Accessory protein||Learn ViroAntibody Discovery Services|
|ORF 7a||Accessory protein||Learn more ViroAntibodies|
|ORF 7b||Accessory protein||Learn ViroAntibody Discovery Services|
|ORF8||Accessory protein||Learn ViroAntibody Discovery Services|
|N||Nucleocapsid protein, forms complexes with genomic RNA, interact with M protein for viral assembly||Learn more ViroAntibodies|
|ORF 9a||Accessory protein||Learn ViroAntibody Discovery Services|
|ORF 9b||Accessory protein||Learn ViroAntibody Discovery Services|
|ORF 10||Accessory protein||Learn ViroAntibody Discovery Services|
The current provided SARS-CoV-2 antibody products are for research use only and are not approved for use in humans or in clinical diagnosis and therapeutics. If you are interested in SARS-CoV-2 antibody discovery and development services for in vitro diagnosis or therapeutic applications, please contact us for more details.