SARS-CoV-2
SARS-CoV-2 Antibody Products by Targets
Fig.1 SARS-CoV-2 genome, transcriptome.
Fig.2 The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Lifecycle.
SARS-CoV-2 Background
Since last December, 2019, an outbreak of a novel coronavirus disease (COVID-19; previously known as 2019-nCoV) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was reported. COVID-19 has subsequently affected various global regions including Americas, Europe, Africa, Western Pacific etc. Even though COVID-19 is an acute resolved disease, it can also be deadly, with a 2% case fatality rate. As of Apr 14, about 1,844,863 cases has been confirmed globally, with 117,021 death cases. Now COVID-19 is an emerging, rapidly evolving situation, and has become a pandemic.
Fig.3 Illustration of a SARS-CoV-2 virion.
Fig.4 Transmission electron micrograph of SARS-CoV-2 virions.
Virus Classification of SARS-CoV-2
SARS-CoV-2 is a positive-sense single-stranded RNA virus, and it’s a strain of severe acute respiratory syndrome-related coronavirus (SARSr-CoV). Coronaviruses consist of four genus: α, β, γ, and δ. The coronaviruses that infect mammals are mainly α and β genus. Among the viruses capable of infecting humans, HCoV-229E and HCoV-NL63 belong to the α coronavirus, and HCoV-OC43, SARS-CoV, HCoV-HKU1, MERS-CoV, and SARS-CoV-2 belong to the β coronavirus.
| SARS-CoV-2 | |
|---|---|
| Virus family | Coronaviridae |
| Virus genus | Betacoronavirus |
| Virus subgenus | Sarbecovirus |
| Virus species | Severe acute respiratory syndrome-related coronavirus |
| Virus strain | Severe acute respiratory syndrome coronavirus 2 |
Table 1. SARS-CoV-2 classification.
Structure of SARS-CoV-2
SARS-CoV-2 was first sequenced by Fan Wu team, and the sequence was published in MN908947. SARS-CoV-2 consists of four structural proteins, including S (spike), E (envelope), M (membrane), and N (nucleocapsid) proteins. S, M and E proteins create the viral envelope together, and N protein holds the SARS-CoV-2 RNA genome. As an important envelope protein, S protein is identified as the protein responsible for virus entry into human cells. In addition, the angiotensin converting enzyme 2 (ACE2) has been demonstrated to be the receptor, and spike/ACE2 interaction might be the mechanism of cell entry.
SARS-CoV-2 Antibodies
Creative Biolabs now provides a variety of SARS-CoV-2 antibodies targeting various proteins (such as SARS-CoV-2 spike protein, SARS-CoV-2 nucleocapsid protein etc.) to meet our clients’ requirements. Please submit your specific SARS-CoV-2 antibody inquiry to us, and we will reply within several hours. For some targets, ready-to-use catalogue is not available. Please reach out to our scientists for antibody discovery services and customized services. For antibody related virology assays, please contact us for a specific assay service. We also provide a full comprehensive suite of secondary antibodies and isotype controls to meet your needs.
| Target | Proposed function | ViroAntibodies |
|---|---|---|
| ORF 1a | Encoded nonstructural proteins (nsp1 to nsp11), essential for viral replication, viral assembly, immune response modulation, etc. | Learn more ViroAntibodies |
| ORF 1b | Encoded nonstructural proteins (nsp12 to nsp16), essential for viral replication | Learn ViroAntibody Discovery Services |
| S | Spike protein, binding to cell receptor and mediate virus-cell fusion | Learn more ViroAntibodies |
| ORF 3a | Accessory protein | Learn ViroAntibody Discovery Services |
| ORF 3b | Accessory protein | Learn ViroAntibody Discovery Services |
| E | Envelope protein, virus assembly and morphogenesis | Learn more ViroAntibodies |
| M | Membrane protein, virus assembly | Learn ViroAntibody Discovery Services |
| ORF6 | Accessory protein | Learn ViroAntibody Discovery Services |
| ORF 7a | Accessory protein | Learn more ViroAntibodies |
| ORF 7b | Accessory protein | Learn ViroAntibody Discovery Services |
| ORF8 | Accessory protein | Learn ViroAntibody Discovery Services |
| N | Nucleocapsid protein, forms complexes with genomic RNA, interact with M protein for viral assembly | Learn more ViroAntibodies |
| ORF 9a | Accessory protein | Learn ViroAntibody Discovery Services |
| ORF 9b | Accessory protein | Learn ViroAntibody Discovery Services |
| ORF 10 | Accessory protein | Learn ViroAntibody Discovery Services |
The current provided SARS-CoV-2 antibody products are for research use only and are not approved for use in humans or in clinical diagnosis and therapeutics. If you are interested in SARS-CoV-2 antibody discovery and development services for in vitro diagnosis or therapeutic applications, please contact us for more details.
References
- Wu, Fan, et al. "A new coronavirus associated with human respiratory disease in China." Nature 579.7798 (2020): 265-269.
- Hoffmann, Markus, et al. "SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor." Cell (2020).
- Lu, Roujian, et al. "Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding." The Lancet 395.10224 (2020): 565-574.
- Kim D W, Lee J Y, Yang J S, et al. The Architecture of SARS-CoV-2 Transcriptome. Cell. 2020. 181, 4, 914-921.e10
- Chakravarty D, Nair S S, Hammouda N, et al. Sex differences in SARS-CoV-2 infection rates and the potential link to prostate cancer. Nature communications biology. 2020, 3, 374
