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Cat#: VRS-0124-YT1128
ViroProbe™ scAAV FIX Probe
Creative Biolabs provides probes that can amplify target-specific signals and detect RNA target expression with high sensitivity and specificity. This scAAV probe is specific for the detection of self-complementary adeno-associated virus (scAAV) FIX gene in cellular and tissue environments. The probe can be used in situ hybridization. The probe is for scAAV (scAAV-LP1-hFIXco vector) research use only and is not approved for use in humans or in clinical diagnosis.
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- Product Summary
- Product Specification
- Target Details
Product Summary
| Product Type : | RNA Probe |
| Probe Type : | Standard Probe |
| Specificity : | Self-complementary adeno-associated virus |
| Target : | scAAV FIX |
| No. of Pairs : | 20 |
| Application : | ISH |
| Application Notes : | This probe is sufficient for staining 20 sections, each with an area of approximately 20 mm x 20 mm. |
| Sample Source : | Formalin-fixed, paraffin-embedded (FFPE) tissue, fresh‑frozen tissue, fixed‑frozen tissue, and cultured cells. |
| Assay Type : | Chromogenic assay; Fluorescent assay |
Product Specification
| Size : | 3 mL |
| Form : | Liquid |
| Concentration : | 1× concentration |
| Storage : | Store at 2-8°C for long term. Refer to the COA file for specifics. |
| Shelf Life : | Stable for two year after receipt when stored as recommended. |
Target Details
| Full Name : | Human factor IX |
| Target Region : | 708-2074 |
| Introduction : | Self-complementary adeno-associated virus (scAAV) is aviral vector engineered from the naturally occurring adeno-associated virus (AAV) to be used as a tool for gene therapy. scAAV vectors bypass the requirement for viral second-strand DNA synthesis, but the packaging capacity of these vectors (∼2.4 kb) is significantly smaller than that of conventional AAV vectors (∼4.8 kb). scAAV has a higher transduction efficiency in animal models compared to conventional rAAV. scAAV-LP1-hFIXco vector containing the LP1 promoter, modified SV40 small t antigen intron, codon-optimized hFIX (hFIXco), and SV40 late polyA, and a deleted 3' trs (Δtrs). scAAV-LP1-hFIXco vectors provide a promising approach for gene therapy of hemophilia B (HB). |
| Alternative Names : | Self-complementary adeno-associated virus; scAAV; human factor IX; hFIX; FIX; scAAV FIX |
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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