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This Rabbit Polyclonal antibody is specific for F protein of Bovine respiratory syncytial virus (BRSV). The antibody can be used for applications: WB, ELISA. The antibody is for Respiratory tract infection disease research use only and is not approved for use in humans or in clinical diagnosis.
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|Product Category||Primary antibody|
|Species Reactivity||Bovine respiratory syncytial virus (BRSV)|
|Specificity||This antibody recognizes bovine residues 483-488 [FPSDEFC] of the 63kD RSV and BRSV Fusion glycoprotein.|
|Immunogen||Synthetic peptide, aa483-488 (FPSDEFC) of the 63kD RSV and BRSV Fusion glycoprotein.|
|Epitope||Bovine residues 483-488 [FPSDEFC] of the 63kD RSV|
|Full Name||Fusion glycoprotein|
|Introduction||During virus entry, induces fusion of viral and cellular membranes leading to delivery of the nucleocapsid into the cytoplasm. The fusogenic activity is inactive untill entry into host cell endosome, where a furin-like protease cleaves off a small peptide between F1 and F2. Interacts directly with heparan sulfate and may participate in virus attachment. Later in infection, proteins F expressed at the plasma membrane of infected cells can mediate fusion with adjacent cells to form syncytia, a cytopathic effect that could lead to tissue necrosis. The fusion protein is also able to trigger p53-dependent apoptosis.|
|Alternative Names||Fusion glycoprotein F2, Fusion glycoprotein F1, F0|
|Related Disease||Respiratory tract infection|
|Virus Species||Bovine respiratory syncytial virus (BRSV)|
|Virus Classification||Negative-sense RNA Viruses|
|Packaging, Storage & Formulations|
|Purification||Affinity chromatography purified|
|Storage||Store at 4°C for short term. Store at -20°C or -80°C for long term. Avoid repeated freeze/thaw cycles. Refer to the COA file for specifics.|
|Buffer||PBS (pH7.2) with 0.02% Sodium Azide and 40% Glycerol|
|Preservative||0.02% Sodium Azide|
|Formulation||PBS (pH7.2) with 0.02% Sodium Azide and 40% Glycerol|
|Purity||>95% as determined by SDS-PAGE|
|Application Notes||WB: 1:250-1:500|
The optimal working dilutions should be determined by the end user.