Lenti-MBGV GP Pseudovirus [GFP, HIV-1 Packaging System] (CAT#: PSV-034CQ)

MBGV GP Pseudovirus is produced by cotransfecting 293T cells with a plasmid encoding MBGV GP protein and a GFP reporter gene. Pseudovirus-containing supernatant was harvested 24 h following transfection. The supernatant was cleared of cell debris by centrifugation and filtered through a 0.45-μm-pore-size filter. The produced pseudoviruses carry MBGV GP proteins, which is a powerful tool for MBGV vaccine and entry inhibitor research.

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Product Details
Virus Packaging ProteinGP
Packaging SystemLentivirus
Packaging Cell293T
Reporter GeneGFP
Application NotesThe pseudovirus can be usd for the following applications:
1. Antibody neutralization assay, Serum neutralization assay.
2. As virus standard alternative in diagnostic assay or others.
3. Drug screening including vaccine development, viral entry inhibitor development.
4. As a safe virology tool to discover the virus entry mechanisms.
Titer>1^8 virus copies/mL
StorageStore at -80°C and stable for 6 months from the date of shipment, avoiding freeze/thaw cycles.
NoteThe pseudovirus can be used under BSL-2 conditions. Please reach out to our scientists for detailed instructions or guidelines of the pseudovirus.
Pseudovirus Details
Virus FamilyFiloviridae
Virus SpeciesMBGV
Virus ClassificationNegative-sense RNA Virus
Related DiseaseMBGA
IntroductionMarburg viruses (MBGV) are enveloped, single negative-stranded RNA viruses belonging to the family Filoviridae. The viruses are the most deadly human-disease-causing agents (biosafety level-4 pathogens ). MBGV infection in humans is often associated with severe hemorrhagic fever and high mortality. MBGV contains a transmembrane glycoprotein (GP) which is heavily glycosylated with both N-linked carbohydrates (including high-mannose oligosaccharides) and O-linked carbohydrates. GP forms the trimeric spikes that occupy the entire surface of the virion. It is responsible for cellular binding and fusion. Therefore, GP is a key target for preventing MBGV infections. Ssubstances that directly interact with GP might interfere with filovirus infection by preventing viral entry into and/or fusion with the target cells.
Alternative NamesGP; MARV GP; MARV_gp4
Gene ID920945
All products and services are intended for Research Use Only, and NOT to be used in diagnostic or therapeutic procedures.

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