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The CHO cell lines expressing HCV E1 envelope proteins were infected with VSVΔG* which encodes the GFP gene instead of the glycoprotein gene. After 16 h the infected cell supernatants were collected and the pseudotyped viruses were purified by centrifugation through sucrose density gradients. The produced pseudoviruses carry HCV E1 proteins, which is a powerful tool for HCV envelope protein function research.
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|Virus Packaging Protein||E1|
|Packaging Cell||CHO cell lines|
|Application Notes||The pseudovirus can be usd for the following applications:|
1. Antibody neutralization assay, Serum neutralization assay.
2. As virus standard alternative in diagnostic assay or others.
3. Drug screening including vaccine development, viral entry inhibitor development.
4. As a safe virology tool to discover the virus entry mechanisms.
|Titer||>1^8 virus copies/mL|
|Storage||Store at -80°C and stable for 6 months from the date of shipment, avoiding freeze/thaw cycles.|
|Note||The pseudovirus can be used under BSL-2 conditions. Please reach out to our scientists for detailed instructions or guidelines of the pseudovirus.|
|Virus Classification||Positive-sense RNA Virus|
|Related Disease||Hepatitis C|
|Introduction||Hepatitis C virus (HCV) is the most important causative agent of posttransfusion and sporadic non-A non-B hepatitis, infecting more than 200 million people worldwide. HCV infection becomes chronic in most cases and may eventually result in hepatitis, liver cirrhosis, and hepatocellular carcinoma. The HCV genome encodes two envelope glycoproteins (E1 and E2), which are thought to be responsible for receptor binding and membrane fusion resulting in virus penetration.|
|Alternative Names||HCV E1; Envelope glycoprotein; Structural polyprotein|