Certificate of Analysis Lookup
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Lot Number
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This Human Monoclonal antibody is specific for S protein. The antibody can be used for applications: ELISA, FC, Neut, Therapeutic. The antibody is for research use only and is not approved for use in humans or clinical diagnosis.
(Note: Please select the requirements to fit you project. If you have any other requirements, please specify. If no specific requirements, you don't need to select any button.)
Product Summary | |
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Product Catetory | Primary Antibody |
Target | S |
Host | Human |
Species Reactivity | SARS-CoV-2 |
Clonality | Monoclonal |
Application | ELISA, FC, Neut, FuncS |
Product Details | |
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Specificity | This antibody reacts with S of SARS-CoV-2. |
Clone | XX0408 |
Immunogen | SARS-CoV-2 |
Isotype | IgG1 |
Conjugation | Unconjugated |
Antigen Details | |
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Full Name | Spike glycoprotein |
Introduction | The spike (S) glycoprotein of coronaviruses contains protrusions that will only bind to certain receptors on the host cell. The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. It's been reported that 2019-nCoV can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity. The main functions for the Spike protein are summarized as: Mediate receptor binding and membrane fusion; Defines the range of the hosts and specificity of the virus; Main component to bind with the neutralizing antibody; Key target for vaccine design; Can be transmitted between different hosts through gene recombination or mutation of the receptor binding domain (RBD), leading to a higher mortality rate. |
Gene ID | 43740568 |
UniProt ID | P0DTC2 |
Alternative Names | S-protein; SARS-CoV2; SARS Coronavirus 2; SARS-CoV-2; SARS CoV 2; 2019-nCoV; Severe acute respiratory syndrome coronavirus 2; Spike protein; S protein; SARS-CoV 2 S protein; S glycoprotein; E2; Peplomer protein; SARS-CoV2 |
Related Disease | COVID-19 |
Virus Details | |
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Virus Family | Coronaviridae |
Virus Species | SARS-CoV-2 |
Virus Classification | Positive-sense RNA Virus |
Packaging, Storage & Formulations | |
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Purification | Immobilized Metal Affinity Chromatography |
Storage | This antibody should be stored at 4°C for short term without detectable loss of activity. For long term, antibody products should be stored at -20°C or below. Avoid multiple freeze-thaw cycles. |
Buffer | PBS |
Form | Liquid |
Formulation | PBS, 0.02% Proclin 300 |
Concentration | 1.0 mg/mL |
Purity | > 95 % as determined by SDS-PAGE and SEC-HPLC. |
Application Notes | |
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Application | ELISA, FC, Neut, FuncS |
Application Notes | The optimal working dilutions should be determined by the end user. |