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Creative Biolabs has been setting the standard in quality virology research reagents for over 10 years.
Human EphrinB2-overexpressed 293T pseudohost is produced by transfection 293T cells with a lentiviral vector encoding human EphrinB2 proteins. This stable cell line express human EphrinB2 proteins on the cell surface, and it can be used for drug/vaccine/viral inhibitor screening, neutralizing antibody screening and serum neutralization assay.
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|Application Notes||The pseudohost can be usd for the following applications:|
1. Antibody neutralization assay, Serum neutralization assay.
3. Drug screening including vaccine development, viral entry inhibitor development.
4. Virus entry mechanism discovery.
|Mycoplasma Testing||The cell line has been screened using the luciferase based mycoplasma detection kit to confirm the absence of mycoplasma species.|
|Quality Control||Cultures are screened for the presence of bacteries, yeast, fungi and mycoplasma (DNA amplification). Growth media are also certified based on U.S. Public Health Service Guidelines.|
|Storage||Cells must be thawed immediately upon receipt and grown according to handling procedures to ensure cell viability and proper assay performance. DO NOT FREEZE the cells upon receipt as it may result in irreversible damage to the cell line. After recovery, the cells can be stored at -80°C or liquid nitrogen (-150°C to -190°C) for long term.|
|Note||We cannot guarantee cell viability if the cells are not thawed immediately upon receipt. Avoid multiple freeze/thaw cycles.|
|Introduction||EphrinB2 is a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. EphrinB2 is essential for vasculogenesis and axonal guidance and is expressed on endothelial cells, neurons and smooth muscle cells surrounding small arteries and arterioles. EphrinB2 has been shown to specifically bind to the attachment (G) glycoprotein of Nipah virus and as the virus entry receptor.|
|Alternative Names||HTKL; EPLG5; Htk-L; LERK5|